Japanese
 NBRP Rat No: 0650 Strain Name: F344-LdlrmKyo/Ta Commmon Name: 
 Principal Investigator  Makoto Asahina
 Organization   Takeda Pharmaceutical Company Limited・Research_T-CiRA discovery 
 Address  Shonan ParkB12F-4110

251-8555  Muraokahigashi 2-26-1, Fujisawa-shi, Kanagawa- ken

  Japan
 Telephone    Fax:    makoto.asahina@takeda.com
 Inbred Generations   N5 
   
 Coat Color
 Deposition Status
 
 albino
  Embryo      Sperm      Live Animals
 Usage Restrictions  The use of this biological resource in the commercial enterprises is not permitted in principle.
The recipient of this biological resource in academic organization shall obtain a prior written consent on use of it from the depositor.
In publishing, a citation of the following literature designated by the depositor is required.
The recipient must not provide this resource to bystanders.
After finishing the defined period in the contract, the recipient requires immediate stop of breeding and euthanasia of all animals derived from this biological resource. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene LDLR: Low density lipoprotein receptor
 Origin F344/NSlc rats having an induced mutation in the Ldlr gene were was established by gene-driven ENU mutagenesis.
 
 Strain Characteristics This strain possesses a missense mutation (C160S) inLdlr gene and shows higher levels of plasma total cholesterol and LDL cholesterol than the wild type rats.
 
 Breeding Conditions  
 Genotyping  
 References  Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats.
Asahina M, Mashimo T, Takeyama M, Tozawa R, Hashimoto T, Takizawa A, Ueda M, Aoto T, Kuramoto T, Serikawa T.
Biochem Biophys Res Commun. 2012 Feb 17;418(3):553-8.