Japanese
 NBRP Rat No: 0656 Strain Name: F344-Lgi1m1Kyo Commmon Name: Lgi1 mutant rat
 Principal Investigator  Tomoji Mashimo
 Organization    The University of Tokyo, The Institute of Medical Science Laboratory Animal Research Center
 Address  4-6-1 Shirokanedai-Minatoku-Tokyoto

108-8639 

  Japan
 Telephone  03-6409-2489  Fax:    mashimo@ims.u-tokyo.ac.jp
 Inbred Generations   N10 (NOV, 2011) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Lgi1
 Origin Developped by gene driven ENU mutagenesis. Lgi1-mutant rats carrying a missense mutation (L385R). 
 Strain Characteristics This rats carrying a missense mutation (L385R) in Lgi1 gene and shows high susceptibility to sound-induced, generalized tonic-clonic seizures.
 
 Breeding Conditions Good breeding performance. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/lgi1m1.pdf">Genotyping protocol for Lgi1</a> 
 References  Kinboshi M, Shimizu S, Tokudome K, Mashimo T, Serikawa T, Ito H, Takahashi R, Ikeda A, Ohno Y.
Imbalance of glutamatergic and GABAergic neurotransmission in audiogenic seizure-susceptible Leucine-rich glioma-inactivated 1 (Lgi1)-mutant rats.
Heliyon. 2023 Jul 5;9(7):e17984.

Kinboshi M, Shimizu S, Mashimo T, Serikawa T, Ito H, Ikeda A, Takahashi R, Ohno Y.
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.
Int J Mol Sci. 2019 Feb 26;20(5):1013.

Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.

"A rat model for LGI1-related epilepsies.
Baulac S, Ishida S, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T.
Hum Mol Genet. 2012 Aug 15;21(16):3546-57.