Japanese
 NBRP Rat No: 0665 Strain Name: UPL/CasTakeu Commmon Name: UPL
 Principal Investigator  Noriko Takeuchi
 Organization   Meijo University the pharmaceutical department
 Address  150 Yagotoyama, Tenpaku-ku, Nagoya-shi, Aichi

468-8503 Nagoya-shi

  Japan
 Telephone  052-839-2684  Fax:  052-834-8090  ntakeuch@meijo-u.ac.jp
 Inbred Generations    F?+1+9 (Murch 20112) 
   
 Coat Color
 Deposition Status
 
 albino（ｃ）
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Gja8: gap junction membrane channel protein alpha 8
 Origin This mutant strain showing hereditary cataract was detected in Sprague-Dawley rat colony.
 
 Strain Characteristics Homozygous rats show early-onset cataract and heterozygous rats show late-onset cataract. A candidate gene for formation of cataracts in UPL rats was mapped to rat chr 2, and the missense mutation （R340W） in connexin 50 (Cx50/Gja8) gene was a strong candidate.
 
 Breeding Conditions  
 Genotyping  
 References  Tomohiro M, Maruyama Y, Yazawa K, Shinzawa S, Mizuno A.
The UPL rat: a new model for hereditary cataracts with two cataract formation types.
Exp Eye Res. 1993 Oct;57(4):507-10.

Tomohiro M, Aida Y, Inomata M, Ito Y, Mizuno A, Sakuma S.
Immunohistochemical study of calpain-mediated alpha-crystallin proteolysis in the UPL rat hereditary cataract.
Jpn J Ophthalmol. 1997 May-Jun;41(3):121-9.

Nabekura T, Koizumi Y, Nakao M, Tomohiro M, Inomata M, Ito Y.
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine.
Exp Eye Res. 2003 Feb;76(2):169-74.

Nabekura T, Tomohiro M, Ito Y, Kitagawa S.
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
Toxicology. 2004 Apr 15;197(2):177-83.

Nagai N, Ito Y.
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
Toxicology. 2007 Dec 5;242(1-3):7-15. Epub 2007 Sep 8.

Nagai N, Ito Y, Okamura H.
Involvement of interleukin 18 in cataract development in hereditary cataract UPL rats.
J Biochem. 2007 Nov;142(5):597-603.

Nagai N, Ito Y, Takeuchi N, Usui S, Hirano K.
Comparison of the mechanisms of cataract development involving differences in Ca2+ regulation in lenses among three hereditary cataract model rats.
Biol Pharm Bull. 2008 Nov;31(11):1990-5.