Japanese
NBRP Rat No: 0666
Strain Name
:
DA-
Tyr
em1Kyo
Commmon Name: DA albino
Principal Investigator
Tomoji Mashimo
Organization
The University of Tokyo, The Institute of Medical Science Laboratory Animal Research Center
Address
4-6-1 Shirokanedai-Minatoku-Tokyoto
108-8639
Japan
Telephone
03-6409-2489
Fax:
mashimo@ims.u-tokyo.ac.jp
Inbred Generations
F2
Coat Color
Deposition Status
albino
Embryo
Sperm
Live Animals
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Tyrosinase
Origin
The strain having a Endonuclease-induced mutation in Tyr gene was established by TAL effector nuclease obtained from Cellectis bioresearch Inc.
Strain Characteristics
This rats show albino phyenotype on the DA/Slc background.
Breeding Conditions
good breeding performance
Genotyping
PCR. wild: 260-bp, mutant: 132-bp. primers: TTGCATAAATTGGTTTTCACAGA, ATTTAAACATGAAAATATTACCTTCCA
References
Mashimo T, Kaneko T, Sakuma T, Kobayashi J, Kunihiro Y, Voigt B, Yamamoto T, Serikawa T.
Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes.
Sci Rep. 2013;3:1253.