Japanese
 NBRP Rat No: 0680 Strain Name: DA.PVG.1AV1-(D1Rat32-D1Rat51)/Kini Commmon Name: DA.PVG.1AV1-Eae30
 Principal Investigator  Tomas Olsson
 Organization   Karolinska Institutet 
 Address  CMM, Karolinska University Hospital, 171 76,

L8:04, Stockholm

  Sweden
 Telephone  +46 8 51776258  Fax:  +46 8 51775562  tomas.olsson@ki.se
 Inbred Generations   Congenic strain was establiesh using a “speed congenic” strategy in 2010. Since then, the strain was kept as inbred. 
   
 Coat Color
 Deposition Status
 
 Agouti
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others Immune and Inflammatory Diseases, Neurological Diseases (Brain Inflammation and Demyelination)
  Control Strains   Reporter gene Strains  
 Gene > 47 Mb
 Origin Inbred Dark Agouti (DA) rats were originally obtained from the Zentralinstitut für Versuchstierzucht (Hannover, Germany) and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Colonies have thereafter been established at Karolinska Institutet (DA/Kini and PVG.1av1/Kini).The DA.PVG.1AV1-(D1Rat32-D1Rat51) congenic strain was established using the marker assisted selection (Wakeland et al. 1997).  
 Strain Characteristics  
 Breeding Conditions Good breeding performance.  
 Genotyping Flanking markers inside the congenic fragment: D1Rat32 and D1Rat51. 
 References  Nohra R, Beyeen AD, Guo JP, Khademi M, Sundqvist E, Hedreul MT, Sellebjerg F, Smestad C, Oturai AB, Harbo HF, Wallström E, Hillert J, Alfredsson L, Kockum I, Jagodic M, Lorentzen J, Olsson T. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14. PMID: 20072140. Becanovic K, Wallstrom E, Kornek B, Glaser A, Broman KW, Dahlman I, Olofsson P, Holmdahl R, Luthman H, Lassmann H, Olsson T. New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol. 2003 Jan 15;170(2):1062-9. PMID: 12517974.