Strains

Japanese

NBRP Rat No: 0694

Strain Name: F344-Il2rg^em7Kyo

Commmon Name: XSCID-TALEN

Principal Investigator

Tomoji Mashimo

Organization

The University of Tokyo, The Institute of Medical Science Laboratory Animal Research Center

Address

4-6-1 Shirokanedai-Minatoku-Tokyoto

108-8639

Japan

Telephone

03-6409-2489

Fax:

mashimo@ims.u-tokyo.ac.jp

Inbred Generations

Coat Color

Deposition Status

albino (c)

Embryo Sperm Live Animals

Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.

Genetic Status

Inbred

Segregating

Congenic

Consomic

Recombinant

Coisogenic

Spont. Mutant

Transgene

Ind. Mutant

Others

Comercial Availability

Research Category

Diabetes Obesity

Neurobiology

Ophthalmology

Dentistry

Cardio- Hypertension

Oncology

Metabolism

Otorhinology

Immunology

Infectious Disease

Osteology

Internal Medicine

Dermatology

Reproduction

Development

Behavior

Hematology

Urology

Pharmacology

Others

Control Strains

Reporter gene Strains

Gene

interleukin 2 receptor gamma (Il2rg)

Origin

The strain having a Endonuclease-induced mutation in Il2rg gene was established by TAL effector nuclease obtained from Dr. Yamamoto at Hiroshima University.

Strain Characteristics

This strain shows severe combined immunodeficiency caused by a 7-bp deletion in the exon 2 of Il2rg gene.

Breeding Conditions

Genotyping

References

Rigatti LH, Toptan T, Newsome JT, Moore PS, Chang Y.
Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay.
mSphere. 2016 Dec 21;1(6). pii: e00334-16.

Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T.
Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.
Sci Rep. 2013 Nov 29;3:3379.