NBRP Rat No: 0078 Strain NameDRH/Seac Commmon Name: 
 Principal Investigator  Masaki Takeuchi
 Organization   Seac Yoshitomi, LTD 
 Address  955 Koiwai Yoshitomi-cho, Chikujo-gun

871-8550 Fukuoka

 Telephone  0979-22-9577  Fax:  0979-24-1955  Takeuchi.Masaki@me.m-pharma.co.jp
 Inbred Generations   F41+?+33(March 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin DRH was established by selective mating of the 3'-Me-DAB resistant progeny of closed colony Donryu rats at Osaka University in 1981. Introduced to Seac Yoshitomi, LTD. in 1991. 
 Strain Characteristics Resistant to carcinoma. 
 Breeding Conditions  
 Genotyping Biochemical gene test and immunological gene test 
 References  Higashi K, Denda A, Higashi T, Hiai H.
Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain.
Comparative Medicine 54(4):373-377, 2004.

Liu H, Higashi K, Hiai H.
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Cancer Sci. 2005 Mar;96(3):164-9.

Hiai H, Liu H, Omi N, Tanuma J, Higashi K.
DRH strain rats: Genetic resistance to chemical hepatocarcinogenesis.
Trends in Cancer Research 2: 127-134, 2006.

Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.