Japanese
 NBRP Rat No: 0700 Strain Name: DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini Commmon Name: DA.PVG.1AV1-Vra4
 Principal Investigator  Tomas Olsson
 Organization   Karolinska Institutet 
 Address  CMM, Karolinska University Hospital, 171 76,

L8:04, Stockholm

  Sweden
 Telephone  +46 8 51776258  Fax:  +46 8 51775562  tomas.olsson@ki.se
 Inbred Generations   Congenic strain was established by transfer of the Vra4 segment andvanced intercross line DAxPVG.AV1 and backcrossed for 9 generetaion before kept as inbread. 
   
 Coat Color
 Deposition Status
 
 Agouti
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development and the characterization of the strain has been published in this article:
Harnesk K, Swanberg M, Öckinger J, Diez M, Lidman O, Wallström E, Lobell A, Olsson T, Piehl F. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. J Immunology. 2008 PMID:18292553 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene 10,5Mb (positionally cloned to CIITA gene)
 Origin Inbred Dark Agouti (DA) rats were originally obtained from
the Zetralinstitut für Versuchstierzucht (Hanover,
Germany) and Piebald Virol Glaxo (PVG) from Harlan UK
Limited (Blackthorn, UK). Congenic strain was established by transfer of the defined Vra4 segment selected from male donors of G8 generation of a DAxPVG1.AV1 andvanced intercross line. Subsequential backcrossing
for 9 generations. 
 Strain Characteristics Lower expression of MHC class II on B cells, milder disease course due to EAE compared to DA. 
 Breeding Conditions Good breeding performances. 
 Genotyping Flanking marker inside the congenic fragment: D10Got6 and D10Rat184. 
 References  Harnesk K, Swanberg M, Öckinger J, Diez M, Lidman O, Wallström E, Lobell A, Olsson T, Piehl F. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. J Immunology. 2008 PMID:18292553