Japanese
 NBRP Rat No: 0699 Strain Name: DA.PVG.1AV1-(D4Rat107-D4Got132)/Kini Commmon Name: DA.PVG.1AV1-Eae20
 Principal Investigator  Tomas Olsson
 Organization   Karolinska Institutet 
 Address  CMM, Karolinska University Hospital, 171 76,

L8:04, Stockholm

  Sweden
 Telephone  +46 8 51776258  Fax:  +46 8 51775562  tomas.olsson@ki.se
 Inbred Generations   Congenic strain was establiesh using a conventional congenic strategy with more than 13 backcross generations in 2005. Since then, the strain was kept as inbred.  
   
 Coat Color
 Deposition Status
 
 Agouti
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development and the characterization of the strain has been published in this article:
Maja Jagodic, Monica Marta, Kristina Becanovic, Jian Rong Sheng, Rita Nohra, Tomas Olsson and Johnny C. Lorentzen. Resolution of a 16.8-Mb Autoimmunity-Regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence for Epistasis; J Immunol 2005; 174:918-924. PMID: 15634914  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene > 8Mb
 Origin Inbred Dark Agouti (DA) rats were originally obtained from the Zentralinstitut für Versuchstierzucht (Hannover, Germany) and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Congenic strain was established by selective transferring of PVG alleles in the interval between D4Rat137 and D4Kiru157 onto DA background in minimum of 13 backcross generations.  
 Strain Characteristics Protection against experimental autoimmune encephalomyelitis (EAE) compared to the susceptible parental DA strain. 
 Breeding Conditions Good breeding performance.  
 Genotyping Flanking markers inside the congenic fragment: D4Rat107-D4Got132. 
 References  Becanovic K, Bäckdahl L, Wallström E, Aboul-Enein F, Lassmann H, Olsson T, Lorentzen JC. Paradoxical effects of arthritis-regulating chromosome 4 regions on myelin oligodendrocyte glycoprotein-induced encephalomyelitis in congenic rats. Eur J Immunol. 2003 Jul;33(7):1907-16. PMID: 12811851.
Maja Jagodic, Monica Marta, Kristina Becanovic, Jian Rong Sheng, Rita Nohra, Tomas Olsson and Johnny C. Lorentzen. Resolution of a 16.8-Mb Autoimmunity-Regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence for Epistasis; J Immunol 2005; 174:918-924. PMID: 15634914