Japanese
 NBRP Rat No: 0080 Strain NamePVG/Seac Commmon Name: Piebald Virol Glaxo
 Principal Investigator  Masaki Takeuchi
 Organization   Seac Yoshitomi, LTD 
 Address  955 Koiwai Yoshitomi-cho, Chikujo-gun

871-8550 Fukuoka

 JAPAN
 Telephone  0979-22-9577  Fax:  0979-24-1955  Takeuchi.Masaki@me.m-pharma.co.jp
 Inbred Generations   F27+32 (April 2012) 
   
 Coat Color
 Deposition Status
 
 black-hooded (a,B,C,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Harlan Olac > Seac Yoshitomi, LTD (1990) 
 Strain Characteristics It is used as a donor or recipient in organ transplant experiments. It is also used as an adjuvant arthritis model. 
 Breeding Conditions  
 Genotyping biochemical genetic examination and immunological genetic examination  
 References  Sung SY, Lin YW, Wu CC, Lin CY, Hsu PS, Periasamy S, Nagarajan B, Hsieh DJ, Tsai YT, Tsai CS, Lin FY.
Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats.
Biomater Sci. 2023 Mar 28;11(7):2566-2580.

Lin YW, Tsai CS, Huang CY, Tsai YT, Shih CM, Lin SJ, Li CY, Lin CY, Sung SY, Lin FY.
Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy.
Biomedicines. 2022 May 7;10(5):1089.

Lin FY, Shih CM, Huang CY, Tsai YT, Loh SH, Li CY, Lin CY, Lin YW, Tsai CS.
Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats.
Cardiovasc Drugs Ther. 2021 Dec;35(6):1111-1127.

Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M.
Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.
BMC Genomics. 2016 Aug 9;17:593.

Yoshimi K, Kaneko T, Voigt B, Mashimo T.
Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform.
Nat Commun. 5:4240, 2014.

Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.

Nakano T, Lai CY, Goto S, Hsu LW, Kawamoto S, Ono K, Chen KD, Lin CC, Chiu KW, Wang CC, Cheng YF, Chen CL.
Immunological and regenerative aspects of hepatic mast cells in liver allograft rejection and tolerance.
PLoS One. 2012;7(5):e37202.