NBRP Rat No: Strain NameExHC/Seac Commmon Name: Exogenously hypercholesterolemic rat
 Principal Investigator  Hidefumi Yukimasa
 Organization   Takeda Chemical Industries, Ltd. 
 Address  2-17-85, jusohonmati, yodogawa-ku

532-8686 Osaka

 Telephone  06-6300-6868  Fax:  06-6300-6207  Yukimasa_Hidefumi@takeda.co.jp
 Inbred Generations    
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  "USER" shall not utilize "THE RESOUCE (ExHC/Seac)" for research aimed at discovering or validating drug candidates. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Isolated from Sprague-Dawley (SD/Jcl) rats by Imai and Matsumura by selection for high serum cholesterol under high cholesterol diet for 7 days (app. 250 mg/dl, normal 100 mg/dl) in 1973. Kyushu University > Seac Yoshitomi, LTD. 1993 
 Strain Characteristics Develop hypercholesterolemia for exogenous cholesterol. Hyperresponsivity to dietary cholesterol (Imaizumi et al. 1992).  
 Breeding Conditions When high cholesterol diet is not given to the ExHC/Seac rats, breeding performance is similar to that of SD strain. Significant QTLs for serum total cholesterol levels were revealed on chromosomes 5 and 14. A suggestive QTL for the trait was also detected on chromosome 3. 
 References  Tanaka Y, Nagao K, Nakagiri H, Nagaso T, Iwasa Y, Mori H, Asahina M, Imaizumi K, Sato M.
Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats.
Lipids Health Dis. 13:19, 2014.

Asahina M, Sato M, Imaizumi K.
Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.
J Lipid Res. 46(10):2289-2294, 2005.

Imai Y, Matsumura H.
Genetic studies on induced and spontaneous hypercholesterolemia in rats.
Atherosclerosis. 1973 Jul-Aug;18(1):59-64.