NBRP Rat No: 0026 Strain NameKDP/Tky Commmon Name: KDP, Komeda diabetes-prone rat
 Principal Investigator  Eiichi Kawamoto
 Organization   Tokyo Medical University Institution: Animal Research Center
 Address  6-1-1 Shinjuku, Shinjuku-ku,

160-8402 Tokyo

 Telephone  03-3351-6141  Fax:  03-3350-8689  kawamoto@tokyo-med.ac.jp
 Inbred Generations   F27+20 
 Coat Color
 Deposition Status
 black hooded (a,B,C,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability  Japan SLC,Inc. 
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Cblb: Casitas B-lineage lymphoma b, RT1u
 Origin Komeda diabetes-prone rat developed by Komeda from Long-Evans Tokushima Lean (LETL) rat at Tokyo Medical College in 1996. Komeda non Diabetic Rats were established simultaneusely as controls (Komeda, 1998). 
 Strain Characteristics KDP rats show 100% development of moderate to severe insulitis within 220 day of age. The cumulative frequency of IDDM was 70% at 120 d of age, and reached 82% within 220 d of age. 
 Breeding Conditions Homozygous Iddm/kdp1males are infertile. Homozygous females are fertile but difficult to breed. Maintained by crossing heterozygotes of the Iddm/kdp1 locus. 
 Genotyping Cblb mutation is detected by PCR-RFLP. 
 References  Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S.
Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.
Diabetes. 56(2):506-12, 2007.

Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 31(4):391-4, 2002.

Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y.
Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats.
Endocr J. 45(6):737-44, 1998.

Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y, Suda S, Ito H, Serikawa T, Komeda K.
A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.
J Clin Invest. 15;100(8):2015-21, 1997.