Japanese
 NBRP Rat No: 0084 Strain Name: F344.CVD-Unc5ccvd/Kyo Commmon Name: F344.CVD-<i>Unc5h3<sup>cvd</sup></i>, cerebellar vermis defect
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   N12F16 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Unc5c: unc-5 homolog C (C. elegans)
 Origin Spontanious mutation from LEW inbred at Osaka Prefecture University in 1992. A congenic strain was produced by backcrosses to F344/NSlc strain at Kyoto University. 
 Strain Characteristics Hereditary cerebellar vermis defect. Mutant rats exhibit hind-leg paralysis from about 14 days old. Gross pathology showes the cerebellar vermis defect, fused cerebellar hemispheres and cyst formation. Ectopic dysplastic cerebellar tissues exist in the cerebello-pontine junctional zones. Mild disarrangement of lamination was also observed in the fused cerebellar hemispheres (Kuwamura 1994). 
 Breeding Conditions Good breeding performance. Sib mating between homorozygous female and heterozygous male. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Unc5c_cvd_en.pdf">Genotyping protocol for Unc5c</a> 
 References  Kuramoto T, Kuwamura M, Serikawa T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Brain Res Mol Brain Res. 122(2): 103-108, 2004.

Kuwamura M, Yoshida T, Yamate J, Kotani T, Sakuma S.
Hereditary cerebellar vermis defect in the Lewis rat.
Dev Brain Res. 83: 294-298, 1994.

Kuwamura M, Yoshida T, Ishida A, Tsudzuki M, Yamate J, Kotani T, Sakuma S.
Cerebellar vermis defect: a new neurological mutation in the rat.
J Hered. 87(2): 161-162, 1996.

Kuwamura M, Yoshida T, Yamate J, Kotani T, Sakuma S, Tsudzuki M.
Perivascular external granule cells in hereditary cerebellar vermis defect rat: pathogenesis of cerebellar cortical dysplasia.
J Vet Med Sci. 58(9): 875-879, 1996.

Kuwamura M, Ishida A, Yamate J, Kato K, Kotani T, Sakuma S.
Chronological and immunohistochemical observations of cerebellar dysplasia and vermis defect in the hereditary cerebellar vermis defect (CVD) rat.
Acta Neuropathol. 94: 549-556, 1997.

Kuwamura M, Shirota A, Yamate J, Kotani T, Sakuma S.
Analysis of aberrant neuronal migrations in the hereditary cerebellar vermis defect (CVD) rat using bromodeoxyuridine-immunohistochemistry.
Acta Neuropathol. 95: 143-148, 1998.

Kuwamura M, Morikawa T, Yamate J, Kato K, Kotani T, Sakuma S.
Glial pathology in development of cerebellar dysplasia in the hereditarycerebellar vermis defect (CVD) rat.
Acta Neuropathol. 99: 305-309, 2000.

Kuwamura M, Shirota A, Takada A, Yamate J, Kotani T, Sakuma S.
Spontaneous and ethyl-nitrosourea-induced medullomyoblastomas in cerebellarvermis defect (CVD) mutant rat.
Acta Neuropathol. 99: 285-288, 2000.