Japanese
 NBRP Rat No: 0095 Strain Name: BUF.ACI-(D4Rat226-D4Rat109)/Ncc Commmon Name: BUF.ACI-<i>Gcr1b</i>
 Principal Investigator  Toshikazu Ushijima
 Organization   National Cancer center Carcinogenesis Division
 Address  5-1-1 Tsukiji, Chuo-ku

104-0045 Tokyo

  JAPAN
 Telephone  03-3547-5240  Fax:  03-5565-1753  tushijim@ncc.go.jp
 Inbred Generations   N7F9 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin This congenic strain is homozygous for the ACI/N <i>Gcr1b</i> allele (on chr.4) on the BUF/Nac background. <br />
ACI/N rats are susceptible and BUF/Nac rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. By using ACI x (ACIxBUF) F1 backcross rats, one dominant susceptibility gene, <i>Gcs1</i> (Gastric cancer susceptibility gene 1), and three dominant resistance genes, <i>Gcr1</i> (Gastric cancer resistance gene 1), <i>Gcr2</i> and <i>Gcr3</i> have been mapped on chromosome 15, 4, 3 and 16 respectively by QTL analysis for MNNG-induced stomach carcinogenicity (Ushijima, 2000). (Feb 4, 2008) 
 Strain Characteristics  
 Breeding Conditions Good breeding performance. 
 Genotyping D4Rat226, D4Rat109 
 References  Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M.
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer Res, 60:1092-1096, 2000