Usage Restrictions
In publishing, an acknowledgment to the DEPOSITOR is requested
Origin
This congenic strain is homozygous for the BUF/Nac Gcs1 allele (on chr.15) on the ACI/N background.
ACI/N rats are susceptible and BUF/Nac rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. By using ACI x (ACIxBUF) F1 backcross rats, one dominant susceptibility gene, Gcs1 (Gastric cancer susceptibility gene 1), and three dominant resistance genes, Gcr1 (Gastric cancer resistance gene 1), Gcr2 and Gcr3 have been mapped on chromosome 15, 4, 3 and 16 respectively by QTL analysis for MNNG-induced stomach carcinogenicity (Ushijima, 2000). (Feb 4, 2008)
Breeding Conditions
Good breeding performance.
References
Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M.
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer Res, 60:1092-1096, 2000