NBRP Rat No: 0020 Strain NameWTC/Kyo Commmon Name: WTC
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F86 (March 2012) 
 Coat Color
 Deposition Status
 albino (a,B,c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin WTC was established as a coisogenic strain (tm<+/+>) from TRM (F18) in 1988. A missense mutation (c. 1061 C>T, p. A354V) in the hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene (Ohno et al. 2015). 
 Strain Characteristics Control coisogenic strain of TRM rat (NBRP No.0015). 
 Breeding Conditions Good breeding performance. Sib mating. 
 References  Nagaki Y, Ito K, Kuwahara M.
WTC rat has unique characteristics such as resistant to streptozotocin.
Biochemistry and Biophysics Reports, Volume 8, December 2016, Pages 157&#8211;161

Y. Ohno, S. Shimizu, A. Tatara, T. Imaoku, T. Ishii, M. Sasa, T. Serikawa, T. Kuramoto.
Hcn1 is a tremorgenic genetic component in a rat model of essential tremor.
PLoS One. 2015 May 13;10(5):e0123529.

Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M.
Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.
BMC Genomics. 2016 Aug 9;17:593.

Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.
Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T.
A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.
BMC Genetics 12:91, 2011