Japanese
 NBRP Rat No: 0021 Strain NameWTC.DMY-Mrs2dmy/Kyo Commmon Name: WTC.DMY-<i>dmy</i>
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   N12F32 (April 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin A congenic strain established with a background strain WTC at Kyoto University. 
 Strain Characteristics A congenic strain established with a background strain WTC. The dmy (demyelination) rat is an autosomal recessive mutant strain that exhibits severe myelin breakdown (demyelination) in the CNS and hind limb ataxia. The causative gene is located on rat Chr 17 and the dmy rat has a point mutation in intron 3 of the Mrs2gene (Kuramoto et al, 2011). 
 Breeding Conditions Maintained in heterozygous condition. 
 Genotyping SSLP markers linked with dmy locus
<a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Mrs2_dmy_en.pdf">Genotyping protocol for Mrs2</a> 
 References  Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Gonalons Sintes E, Canto Martorell J, Guenet J-L.
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Mamm Genome. 7: 890-894, 1996.

Kitada K. et al
Determination of the mouse homologous region for the rat dmy locus.
J Exp Anim. Sci. 41:40-43, 2000.

Kuwamura M, Kanehara T, Tokuda S, Kumagai D, Yamate J, Kotani T, Nakane Y, Kuramoto T, Serikawa T
Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat.
Brain Res. 1;1022(1-2):110-6, 2004

Izawa T, Yamate J, Franklin RJ, Kuwamura M.
Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat.
Brain Res. 2010 Aug 19;1349:105-14.

Kuramoto T, Kuwamura M, Tokuda S, Izawa T, Nakane Y, Kitada K, Akao M, Gu&eacute;net JL, Serikawa T.
A mutation in the gene encoding mitochondrial Mg&sup2;+ channel MRS2 results in demyelination in the rat.
PLoS Genet. 2011 Jan 6;7(1):e1001262.

Kuwamura M, Inumaki K, Tanaka M, Shirai M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T.
Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat.
Brain Res. 2011 May 10;1389:161-8.

Shimotsuma Y, Tanaka M, Izawa T, Yamate J, Kuwamura M.
Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.
PLoS One. 2016 Dec 15;11(12):e0168250.