NBRP Rat No: 0103 Strain NameLEW/JmsNgs Commmon Name: LEW/Jms, congenital hydrocephalus rat, 先天性水頭症ラット
 Principal Investigator  Kazutaka Ohsawa
 Organization   Center for Frontier Life Sciences, Nagasaki University Division of Comparative Medicine
 Address  1-12-4, Sakamoto, Nagasaki

852-8523 Nagasaki

 Telephone  095-819-7132  Fax:  095-819-7148  kohsawa@net.nagasaki-u.ac.jp
 Inbred Generations   F71+9+25 (April 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Lewis rats: Tokyo Medical Insitute -> Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980 -> Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maitained out by selective breeding. 
 Strain Characteristics Congenital hydrocephalus. Appearance of hydocephalus rats: about 33% in males, about 13 % in females. 
 Breeding Conditions For an optimal breeding performance, 20% of the colony should develop hydrocephalus. Selection for higher disease occurrence reduces breeding efficiency due to infertle animals. 
 References  ・小児の脳神経9(4):257-264,1984 ラットにおける先天性水頭症の実験モデル
・脳神経37(11):1053-1057,1985 先天性水頭症ラット(LEW/Jms)における脳組織障害について
・小児の脳神経12(1):1-9,1987 先天性水頭症ラット脳の病理学的観察
・脳神経42(6):539-545,1990 先天性水頭症ラット脈絡叢における心房性ナトリウム利尿ペプチド受容体の変動