Japanese
NBRP Rat No: 0103
Strain Name
:
LEW/JmsNgs
Commmon Name: LEW/Jms, congenital hydrocephalus rat, 先天性水頭症ラット
Principal Investigator
Kazutaka Ohsawa
Organization
Center for Frontier Life Sciences, Nagasaki University Division of Comparative Medicine
Address
1-12-4, Sakamoto, Nagasaki
852-8523 Nagasaki
Japan
Telephone
095-819-7132
Fax: 095-819-7148
kohsawa@net.nagasaki-u.ac.jp
Inbred Generations
F71+9+25 (April 2012)
Coat Color
Deposition Status
albino (c)
Embryo
Sperm
Live Animals
Usage Restrictions
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Origin
Lewis rats: Tokyo Medical Insitute -> Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980 -> Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maitained out by selective breeding.
Strain Characteristics
Congenital hydrocephalus. Appearance of hydocephalus rats: about 33% in males, about 13 % in females.
Breeding Conditions
For an optimal breeding performance, 20% of the colony should develop hydrocephalus. Selection for higher disease occurrence reduces breeding efficiency due to infertle animals.
Genotyping
References
・小児の脳神経９（４）：257-264,1984 ラットにおける先天性水頭症の実験モデル
・脳神経３７（１１）：1053-1057,1985 先天性水頭症ラット（LEW/Jms）における脳組織障害について
・小児の脳神経１２（１）：1-9,1987 先天性水頭症ラット脳の病理学的観察
・脳神経４２（６）：539-545,1990 先天性水頭症ラット脈絡叢における心房性ナトリウム利尿ペプチド受容体の変動