NBRP Rat No: 0023 Strain NameWTC.ZI-Atrnzi/Kyo Commmon Name: WTC.ZI-<i>Atrn<sup>zi</sup></i>, WTC.ZI-zi
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   N23F29 (March 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Atrn: attractin
 Origin Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo. A second zi allele carrying line with WTC backgrund was established at Kyoto University WTC.ZI-<i>zi</i>. 
 Strain Characteristics This strain exhibits vacuole formation of CNS and body tremor. The causative gene is <i>Atrm</i> (attractin). 
 Breeding Conditions Heterozygous female and homozygous male are mated. 
 Genotyping 8 bp deletion in intron 12 of Attractin gene
<a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Atrn_zi_en.pdf">Genotyping protocol for Atrn</a> 
 References  Muto Y, Sato K.
Pivotal role of attractin in cell survival under oxidative stress in the zitter rat brain with genetic spongiform encephalopathy.
Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):111-22.

Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, Serikawa T.
Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.
Proc Natl Acad Sci USA, 98 (2): 559-564, 2001

Kuramoto T, Yamasaki K, Kondo A, Nakajima K, Yamada M, Serikawa T.
Production of WTC.ZI-zi rat congenic strain and its pathological and genetic analyses.
Exp Anim, 47: 75-81, 1998