NBRP Rat No: 0143 Strain NameMD/Tama Commmon Name: MD, myelin deficient rat
 Principal Investigator  Nobuaki Tamamaki
 Organization   Graduate School of Medicine, Kyoto University Department of Morphological Brain Science
 Address  Yoshida, Sakyou-ku

606-8501 Kyoto

 Telephone  075-753-4331  Fax:  075-753-4340  tamamaki@mbs.med.kyoto-u.ac.jp
 Inbred Generations   F?+30 (April 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  Need acknowledgement of Drs. CK Csiza, Drs. A Koeppen and KD Barron  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Plp1: proteolipid protein 1
 Origin Dr. Csiza 1988 > Kyoto University 2000 
 Strain Characteristics Mutation locates on X chromosome. 
 Breeding Conditions Sib mating between heterozygous female and wild type male. Carrier female rat looks normal. Possibly low in proliferation. 
 Genotyping RFLP of PCR products

<a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Plp1_md_en.pdf">Genotyping protocol for Plp1</a> 
 References  Dentinger et al. (1982) Brain Res. 344: 255-266.
Marciano et al. (1990) J. Comp. Neurol. 295: 219-234.