Japanese
NBRP Rat No: 0143
Strain Name
:
MD/Tama
Commmon Name: MD, myelin deficient rat
Principal Investigator
Nobuaki Tamamaki
Organization
Graduate School of Medicine, Kyoto University Department of Morphological Brain Science
Address
Yoshida, Sakyou-ku
606-8501 Kyoto
Japan
Telephone
075-753-4331
Fax: 075-753-4340
tamamaki@mbs.med.kyoto-u.ac.jp
Inbred Generations
F?+30 (April 2012)
Coat Color
Deposition Status
albino (c)
Embryo
Sperm
Live Animals
Usage Restrictions
Need acknowledgement of Drs. CK Csiza, Drs. A Koeppen and KD Barron
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Plp1: proteolipid protein 1
Origin
Dr. Csiza 1988 > Kyoto University 2000
Strain Characteristics
Mutation locates on X chromosome.
Breeding Conditions
Sib mating between heterozygous female and wild type male. Carrier female rat looks normal. Possibly low in proliferation.
Genotyping
RFLP of PCR products
<a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Plp1_md_en.pdf">Genotyping protocol for Plp1</a>
References
Dentinger et al. (1982) Brain Res. 344: 255-266.
Marciano et al. (1990) J. Comp. Neurol. 295: 219-234.