Japanese
 NBRP Rat No: 0009 Strain Name: IS-Tlk/Kyo Commmon Name: IS/Kyo-<i>Tlk</i>/Kyo, IS/Kyo-<i>Tlk</i>, Tail anomaly Lethal Kyoto
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F10+F55 (May 2009) 
   
 Coat Color
 Deposition Status
 
 agouti (A,B,C)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Spontanious mutation was found in IS/Kyo inbred (F10) at Kyoto University in 1988. Tlk(Tail anomaly Lethal Kyoto) 
 Strain Characteristics Malformations of the thoracicolumbar vertebrae leading to kyphoscoliosis with restricted spinal canals and compressed spinal cords. Mode of inheritance is unknown. 
 Breeding Conditions Short tail and normal rat are mated. 
 Genotyping  
 References  Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Takano M, Ogawa E, Saitou T, Yamaguchi Y, Asano Y, Serikawa T, Kuramoto T.
Morphological features of adult rats of IS/Kyo and IS-Tlk/Kyo strains with lumbar and caudal vertebral anomalies.
Exp Anim. 2014;63(3):269-75.

Takano M, Katsumata Y, Ogawa J, Ebata T, Urasoko Y, Asano Y, Serikawa T, Kuramoto T.
Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies.
Congenit Anom (Kyoto). 52(1):42-47, 2012