NBRP Rat No: 0010 Strain NameNER/Kyo Commmon Name: NER, Noda epileptic rat, GMS
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F28+42 (March 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability  Japan SLC,Inc. 
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Noda Epileptic Rat derived from Crj: Wistar rats. Developed by A. Noda, 1985. 1997 introduced to Kyoto University (F28).  
 Strain Characteristics Animal model of epilepsy that exhibit spontaneous tonic-clonic convulsions, beginning with neck and forelimb clonus, wild jumping/running, opisthotonic posturing, and evolving to tonic, then clonic convulsion, followed by postictal flaccidity. Ictal cortical and hippocampal EEGs are characterized by high-voltage spikes followed by diffuse spike-and-wave or polyspike-and-wave complexes. Seizure susceptibility to pentylenetetrazol, tossing, and transcorneal electroshock, but not to tactile, photic, or acoustic stimuli, or to transauricular electroshock. No pathologic changes were demonstrated in the CNS. Spontaneous convulsions are controlled by a major autosomal recessive gene for epilepsy, that are comparable to generalized tonic-clonic seizures in humans (Noda, 1998). 
 Breeding Conditions Good breeding performance. 
 References  Kuramoto T, Voigt B, Nakanishi S, Kitada K, Nakamura T, Wakamatsu K, Yoshihara M, Suyama M, Uemura R, Tanaka M, Kuwamura M, Shimizu S, Ohno Y, Sasa M, Serikawa T.
Identification of candidate genes for generalized tonic-clonic seizures in Noda epileptic rat.
Behav Genet. 2017

Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.

Harada Y, Nagao Y, Shimizu S, Serikawa T, Terada R, Fujimoto M, Okuda A, Mukai T, Sasa M, Kurachi Y, Ohno Y.
Expressional analysis of inwardly rectifying Kir4. 1 channels in Noda epileptic rat (NER).
Brain Res. 2013 Jun 23;1517:141-9.

Pandit S, Jeong JA, Jo JY, Cho HS, Kim DW, Kim JM, Ryu PD, Lee SY, Kim HW, Jeon BH, Park JB.
Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats.
J Neurophysiol. 2013 Jul;110(1):95-102.

Ishimaru Y, Chiba S, Serikawa T, Sasa M, Inaba H, Tamura Y, Ishimoto T, Takasaki H, Sakamoto K, Yamaguchi K.
Effects of levetiracetam on hippocampal kindling in Noda epileptic rats.
Brain Res. 2010 Jan 14;1309:104-9.

Maihara, T., Noda, A., Yamazoe, H., Voigt, B., Kitada, K. and Serikawa, T.
Chromosomal mapping of genes for epilepsy in NER: A rat strain with tonic-clonic seizures.
Epilepsia, 41 (8): 941-949, 2000.

Sejima, H., Ito, M., Kishi, K., Noda, A. and Serikawa, T.
Regional excitatory and inhibitory amino acid concentrations in Noda epileptic rat (NER) brain.
Brain Develop, 21: 382-385, 1999.

Jinde, S., Masui, A., Morinobu, S., Takahashi, Y., Tsunashima, K., Noda, A., Yamada, N. and Kato, N.
Elevated neuropeptide Y and corticotropin-releasing factor in the brain of a novel epileptic mutant rat: Noda epileptic rat.
Brain Res., 30 (2): 115-126, 1999.

Iida, K., Sasa, M., Serikawa, T., Noda, A., Ishihara, K., Akimitsu, T., Hanaya, R., Arita, K. and Kurisu, K.
Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER).
Epilepsy Res, 30 : 115-126, 1998

Noda, A., Hashizume, R., Maihara, T., Tomizawa, Y., Ito, Y., Inoue, M., Kobayashi, K., Asano, Y., Sasa, M., Serikawa, T.
NER rat strain, a new type of genetic model in epilepsy research.
Epilepsia, 39 (1): 99-107, 1998.

Sasa、M.,Hanaya, R., Iida, K., Akimitsu, T., Kurisu, K., Noda, A., Kobayashi, K., Asano, Y., Sasa, M. and Serikawa, T.
A novel epilepsy animal model (NER).
Nihon Shinkei Seishin Yakurigaku Zasshi, 17(1): 35-38, 1997 (in Japanese)