Japanese
 NBRP Rat No: 0006 Strain Name: HTX/Kyo Commmon Name: HTx, H-Tx
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F?+54 (March 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin 1981 by Kohn from institutional albino rats of unknown origin at University of Texas. From Juntendo University to Kyoto University in 1992. 
 Strain Characteristics Hydrocephalics can be detected at 1-2 days of age, and survive for 4-5 weeks. Dilatation of the ventricles is restricted to the lateral ventricles (Kohn et al. 1981). Hydrocephalus becomes evident in late gestation and is associated with an abnormality of the cerebral aqueduct (Jones and Bucknall 1988). Overall, penetrance in this strain is 40% but variable between litters, which may indicate the involvement of environmental factors of yet unknown origin, in addition to genetic factors. 
 Breeding Conditions Animals which don't describe the mutant phenotype are selected for mating. 
 Genotyping  
 References  Kim H, Yoshihara M, Suyama M.
Comparative genomic analysis of inbred rat strains reveals the existence of ancestral polymorphisms.
Mamm Genome. 2020 Apr;31(3-4):86-94.

Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Jones HC, Depelteau JS, Carter BJ, Lopman BA, Morel L.
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat.
Mamm Genome 12:22-26, 2001.

Jones HC, Lopman BA, Jones TW, Morel LM.
Breeding characteristics and genetic analysis of the H-Tx rat strain.
European Journal of Pediatric Surgery. 9 Suppl 1: 42-43, 1999.