Origin
Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Introduced to Tokyo Medical College in 1983.
Strain characteristics
Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Sublines of diabetic-prone and diabetic-resistant animals have been developed, and there are also subline differences in the incidence, age of onset, untreated survival time of diabetes, leucopenia and body weight gain which can be attributed to genetic factors (Klöting et al 1987).
Breeding Conditions
For mating injection of insulin once a day. Offspring from affected parents are crossed.
References
Nakhooda AF, Like AA, Chappel CI, Murray FT, Marliss EB.
The spontaneously diabetic Wistar rat. Metabolic and morphologic studies.
Diabetes. 1977 Feb;26(2):100-12.
Like AA, Rossini AA, Guberski DL, Appel MC, Williams RM.
Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.
Science. 1979 Dec 21;206(4425):1421-3.
Chappel CI, Chappel WR.
The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus.
Metabolism. 1983 Jul;32(7 Suppl 1):8-10.