Japanese
NBRP Rat No: 0031
Strain Name
:
BB.PVG-
RT1
u/a
/Tky
Commmon Name: BB.PVG-<i>RT1<sup>u/a</sup></i>
Principal Investigator
Eiichi Kawamoto
Organization
Tokyo Medical University Institution: Animal Research Center
Address
6-1-1 Shinjuku, Shinjuku-ku,
160-8402 Tokyo
JAPAN
Telephone
03-3351-6141
Fax: 03-3350-8689
kawamoto@tokyo-med.ac.jp
Inbred Generations
N11
Coat Color
Deposition Status
albino (c)
Embryo
Sperm
Live Animals
Usage Restrictions
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Origin
A congenic strain with the genetic background of the BB/WorTky strain (RT1.B<sup>u</sup>,D<sup>u</sup>) onto which the MHC locus of PVG.R23 strain (RT1.B<sup>a</sup>,D<sup>a</sup>) has been transferred.
Strain Characteristics
Animals carrying u/u alleles of the MHC locus show diabetes and animals carrying a/a alleles show thyroiditis.
Breeding Conditions
Maintained by crossing heterozygotes u/a allele of the MHC locus.
Genotyping
PCR-RFLP
References
Awata T, Guberski DL, Like AA.
Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II.
Endocrinology. 1995 Dec;136(12):5731-5.