Japanese
 NBRP Rat No: 0032 Strain Name: KZ-Leprfa/Tky Commmon Name: KZ-<i>Lepr<sup>fa</sup></i>, KZF
 Principal Investigator  Eiichi Kawamoto
 Organization   Tokyo Medical University Institution: Animal Research Center
 Address  6-1-1 Shinjuku, Shinjuku-ku,

160-8402 Tokyo

  JAPAN
 Telephone  03-3351-6141  Fax:  03-3350-8689  kawamoto@tokyo-med.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 black hooded (a,B,C,h) or brown hooded ( a,b,C,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Lepr: leptin receptor
 Origin A inbred strain from Zucker-fatty rats which were introduced to Takeda Chemical Industries in 1980. 
 Strain Characteristics An autosomal recessive mutation fatty (fa) was caused of the missense mutation of the Lepr gene. 
 Breeding Conditions Maintained by crossing heterozygotes of the Lepr locus. 
 Genotyping PCR-RFLP
<a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Lepr_fa_en.pdf">Genotyping protocol for Lepr</a> 
 References  Nakanishi S, Kuramoto T, Kashiwazaki N, Yokoi N.
Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at the Tokyo Medical University.
Exp Anim. 2016 Oct 31. [Epub ahead of print]

Liang-Cai Zhao, Xiao-Dong Zhang, Heyo Wang, and Donghai Lin.
1H NMR-BASED METABONOMIC ANALYSIS OF METABOLIC CHANGES OF SERUM AND LIVER IN ZUCKER OBESE RATS.
Taylor & Francis Analytical Letters, 2011, 44, 1579-1590

Zhao LC, Zhang XD, Liao SX, Gao HC, Wang HY, Lin DH.
A metabonomic comparison of urinary changes in Zucker and GK rats.
J Biomed Biotechnol. 2010;2010:431894.