Strain information

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NBRP Rat No: 0148

Strain name: Gunn-Ugt1a1^j/Slc

Commmon Name: Gunn/Slc-j/j, Gunn's (Nonhemolytic jaundiced rat)

Rat Genome Database

Principal Investigator:

Representative DirectorJapan SLC, Inc

Preservation Status:

Embryo Sperm Living Animals

Coat Color

black hooded

Inbred Generations

F32+54

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Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Japan SLC, Inc

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Ugt1a1: UDP glycosyltransferase 1 family, polypeptide A1

Origin

Originated from mutant rat found in Wistar rat.

Strain characteristics

The Gunn rat is a mutant strain of Wistar rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin. Caused by a single guanosine (G) base deletion within the UGT1A1 gene. Animal model of Crigler–Najjar syndrome type I. (Mar 2008)

Breeding Conditions

Sib mating. Heterozygous female and homozygous male are mated. Poor breeding performance.

Genotyping

References

Iyanagi T, Watanabe T, Uchiyama Y.
The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation.
J Biol Chem. 1989 Dec 15;264(35):21302-7.

Additional strain information (Japanese only)

Gunn