Japanese
 NBRP Rat No: 0148 Strain Name: Gunn-Ugt1a1j/Slc Commmon Name: Gunn/Slc-j/j, Gunn's (Nonhemolytic jaundiced rat)
 Principal Investigator  Representative Director
 Organization   Japan SLC, Inc 
 Address  3371-8, Kotoh-cho, Hamamatsu

431-1103 Shizuoka

  Japan
 Telephone  053-486-3178  Fax:  053-486-3156  slc01@jslc.co.jp
 Inbred Generations   F32+54 
   
 Coat Color
 Deposition Status
 
 black hooded
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability  Japan SLC, Inc 
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Ugt1a1: UDP glycosyltransferase 1 family, polypeptide A1
 Origin Originated from mutant rat found in Wistar rat. 
 Strain Characteristics The Gunn rat is a mutant strain of Wistar rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin. Caused by a single guanosine (G) base deletion within the UGT1A1 gene. Animal model of Crigler–Najjar syndrome type I. (Mar 2008) 
 Breeding Conditions Sib mating. Heterozygous female and homozygous male are mated. Poor breeding performance. 
 Genotyping  
 References  Iyanagi T, Watanabe T, Uchiyama Y.
The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation.
J Biol Chem. 1989 Dec 15;264(35):21302-7.