Strains

Japanese

NBRP Rat No: 0153

Strain Name: NAR/Slc

Commmon Name: Nagase analbuminemic rat

Principal Investigator

Representative Director

Organization

Japan SLC, Inc

Address

3371-8, Kotoh-cho, Hamamatsu

431-1103 Shizuoka

Japan

Telephone

053-486-3178

Fax: 053-486-3156

slc01@jslc.co.jp

Inbred Generations

F44+15

Coat Color

Deposition Status

albino (c)

Embryo Sperm Live Animals

Usage Restrictions

Genetic Status

Inbred

Segregating

Congenic

Consomic

Recombinant

Coisogenic

Spont. Mutant

Transgene

Ind. Mutant

Others

Comercial Availability

Research Category

Diabetes Obesity

Neurobiology

Ophthalmology

Dentistry

Cardio- Hypertension

Oncology

Metabolism

Otorhinology

Immunology

Infectious Disease

Osteology

Internal Medicine

Dermatology

Reproduction

Development

Behavior

Hematology

Urology

Pharmacology

Others

Control Strains

Reporter gene Strains

Gene

Origin

Originated from analbuminemic rats found in the closed colony of SD (Jcl:SD).

Strain Characteristics

Analbuminemia. Inherited as an autosomal recessive trait. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. No expression of serum albumin is due to skipping of the exon H caused by a mutation in the intron HI.

Breeding Conditions

Sib mating.

Genotyping

References

Masayuki Fukumoto, Akihiko Soyama, Daisuke Miyamoto, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Mampei Yamashita, Tomohiko Adachi, Kengo Kanetaka, Susumu Eguchi
Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus
Regenerative Therapy. Dec 2025, P1-8. doi: 10.1016/j.reth.2025.04.015

Nagase S, Shimamune K, Shumiya S.
Science. 1979 Aug 10;205(4406):590-1.
Albumin-deficient rat mutant.

Hitomi Y, Sugiyama K, Esumi H.
Suppression of the 5' splice site mutation in the Nagase analbuminemic rat with mutated U1snRNA.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):11-6.