NBRP Rat No: 0153 Strain NameNAR/Slc Commmon Name: Nagase analbuminemic rat
 Principal Investigator  Sadaaki Takagi
 Organization   Japan SLC, Inc 
 Address  3371-8, Kotoh-cho, Hamamatsu

431-1103 Shizuoka

 Telephone  053-486-3178  Fax:  053-486-3156  slc01@jslc.co.jp
 Inbred Generations   F44+15 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability  Japan SLC, Inc 
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Originated from analbuminemic rats found in the closed colony of SD (Jcl:SD). 
 Strain Characteristics Analbuminemia. Inherited as an autosomal recessive trait. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. No expression of serum albumin is due to skipping of the exon H caused by a mutation in the intron HI. 
 Breeding Conditions Sib mating. 
 References  Nagase S, Shimamune K, Shumiya S.
Science. 1979 Aug 10;205(4406):590-1.
Albumin-deficient rat mutant.

Hitomi Y, Sugiyama K, Esumi H.
Suppression of the 5' splice site mutation in the Nagase analbuminemic rat with mutated U1snRNA.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):11-6.