Japanese
 NBRP Rat No: 0166 Strain NameSD-Tg(CAG-Rgn)Slc Commmon Name: RC-Tg, SD-<i>Tg(CAG-RGN)</i>
 Principal Investigator  Sadaaki Takagi
 Organization   Japan SLC, Inc 
 Address  3371-8, Kotoh-cho, Hamamatsu

431-1103 Shizuoka

 Japan
 Telephone  053-486-3178  Fax:  053-486-3156  slc01@jslc.co.jp
 Inbred Generations   F?+2 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The user shall comply with the agreement written by Japan SLC, Inc. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability  Japan SLC, Inc 
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Rgn: regucalcin
 Origin Rats were generated by pronuclear injection of the transgene with a cDNA construct encoding rat regucalcin, a regulatory protein of Ca2+ signaling (Yamaguchi, 2002). (Nov 2009) 
 Strain Characteristics This transgenic strain shows overexpression of regucalcin. Animal model for bone disease as represented by bone loss. The body weight of tg rats is significantly lowered. (Yamaguchi, 2002) (Nov 2009) 
 Breeding Conditions Sib mating. 
 Genotyping  
 References  Yamaguchi M, Morooka Y, Misawa H, Tsurusaki Y, Nakajima R.
Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity.
J Cell Biochem. 2002;86(3):520-9.