Strain information

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NBRP Rat No: 0166

Strain name: SD-Tg(CAG-Rgn)Slc

Commmon Name: RC-Tg, SD-Tg(CAG-RGN)

Rat Genome Database

Principal Investigator:

Representative DirectorJapan SLC, Inc

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

F?+2

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../images/Photos/RC-Tg/651z%20(Large).jpg

Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Japan SLC, Inc

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Rgn: regucalcin

Origin

Rats were generated by pronuclear injection of the transgene with a cDNA construct encoding rat regucalcin, a regulatory protein of Ca2+ signaling (Yamaguchi, 2002). (Nov 2009)

Strain characteristics

This transgenic strain shows overexpression of regucalcin. Animal model for bone disease as represented by bone loss. The body weight of tg rats is significantly lowered. (Yamaguchi, 2002) (Nov 2009)

Breeding Conditions

Sib mating.

Genotyping

References

Yamaguchi M, Morooka Y, Misawa H, Tsurusaki Y, Nakajima R.
Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity.
J Cell Biochem. 2002;86(3):520-9.

Additional strain information (Japanese only)