Japanese
 NBRP Rat No: 0007 Strain Name: KHR/Kyo Commmon Name: KHR, kaken hairless rat
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F36+31 (March 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c,p)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Kaken hairless rat were detected by Kimura from Gunn's rat at Kaken Pharmaceuticals in 1987. 2002 introduced to Kyoto University (F36). 
 Strain Characteristics Hairless. This strain has deletion mutation in <i>Oca2</i>, pink-eyed dilution (Kuramoto, 2005).
A 80-kb deletion was identified in the region containing five basic keratin (<i>krt</i>) genes (Kuramoto, 2010). (Jul 4, 2011) 
 Breeding Conditions Heterozygous female and homozygous male are mated. 
 Genotyping  
 References  Kuramoto T, Gohma H, Kimura K, Wedekind D, Hedrich HJ, Serikawa T.
The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains.
Mamm Genome. 2005 Sep;16(9):712-9.

Takashi Kuramoto, Satoshi Nakanishi, Ken-ichi Yamasaki, Kenta Kumafuji, Yuichi Sakakibara, Yuki Neoda, Akiko Takizawa, Takehito Kaneko, Mito Otsuki, Ryoko Hashimoto, Birger Voigt, Tomoji Mashimo and Tadao Serikawa
Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat
ibc.2010 Volume 2 Article no. 0012