NBRP Rat No: 0193 Strain NameSHR/Izm Commmon Name: 
 Principal Investigator  Yukio Yamori
 Organization   Disease Model Cooperative Research Association 
 Address  Kenju Bldg. 2F86, Jodoji-Shimobanba-cho, Sakyo-ku

606-8413 Kyoto

 Telephone  075-761-2371  Fax:  075-761-2371  dmcra@j.email.ne.jp
 Inbred Generations   F110 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association.
They must also comply with the decisions made by the board of directors. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin The spontaneously hypertensive rat (SHR) was established by selective breeding of outbred Wistar-Kyoto rats which showing hypertension by Prof. Okamoto at Department of Pathology, Kyoto University School of Medicine in 1963 (Okamoto, 1963). To Shimane Institute of Health Science, Shimane University Faculty of Medicine, Graduate School of Human and Environmental Studies, Kyoto University and to DMCRA in 1994. (Jun 1, 2010) 
 Strain Characteristics Hepertention, cardiac hypertrophy, nephrosclerosis and cardiac arrest. Control strain is WKY. 
 Breeding Conditions Good breeding performance. 
 References  Yao H, Nabika T.
Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles.
J Transl Med. 2012 Jul 6;10(1):139.

Yamori,Y et.al. : The Spontaneously Hypertensive Rat. In: Textbook of hypertension,
ed. By Swales,J.D.,Blackwell Scientific Publication, Oxford, 1994,pp447-455