Origin |
The spontaneously hypertensive rat (SHR) was established by selective breeding of outbred Wistar-Kyoto rats which showing hypertension by Prof. Okamoto at Department of Pathology, Kyoto University School of Medicine in 1963 (Okamoto, 1963). To Shimane Institute of Health Science, Shimane University Faculty of Medicine, Graduate School of Human and Environmental Studies, Kyoto University and to DMCRA in 1994. (Jun 1, 2010) |
References |
Yao H, Nabika T. Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles. J Transl Med. 2012 Jul 6;10(1):139.
Yamori,Y et.al. : The Spontaneously Hypertensive Rat. In: Textbook of hypertension, ed. By Swales,J.D.,Blackwell Scientific Publication, Oxford, 1994,pp447-455 |