Japanese
 NBRP Rat No: 0216 Strain Name: LEC(LECSDF1)-Tg(CAG-ATP7B)Tohm Commmon Name: LEC(LECSDF1)-Tg(hATP7B)Tohm, L2-3
 Principal Investigator  Noriyuki Kasai
 Organization   Tohoku University Graduate School of Medicine Institute for Animal Experimentation
 Address  2-1, Seiryo-machi, Aoba-ku, Sendai

980-8575 Miyagi

  Japan
 Telephone  022-717-8178  Fax:  022-717-8180  nkasai@mail.tains.tohoku.ac.jp
 Inbred Generations   F5 
   
 Coat Color
 Deposition Status
 
 cinnamon
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature(s) designated by the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene ATP7B: ATPase, Cu++ transporting, beta polypeptide
 Origin  
 Strain Characteristics  
 Breeding Conditions Good breeding performance. 
 Genotyping  
 References  Meng Y, Miyoshi I, Hirabayashi M, Su M, Mototani Y, Okamura T, Terada K, Ueda M, Enomoto K, Sugiyama T, Kasai N.
Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene.
Biochim Biophys Acta. 5;1690(3):208-19, 2004.