Japanese
 NBRP Rat No: 0219 Strain Name: WT/Jtt Commmon Name: WT, 切歯白墨化ラット（whitish teeth rat）
 Principal Investigator  Kazuyuki Taniguchi
 Organization   Iwate University, Faculty of Agriculture Department of Veterinary Medicine
 Address  3-18-8 Ueda, Morioka

020-8550 Iwate

  Japan
 Telephone  019-621-6207  Fax:  019-621-6209  anatomia@iwate-u.ac.jp
 Inbred Generations   F22 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITEOR. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin In 2001, abnormal incisors that had deteriorated and had a whitish chalk-like appearance were unexpectedly discovered in one male rat among Sprague-Dawley [Crj:CD(SD)IGS] rats (Masuyama, 2005). After that, this mutant phenotype was maintained by sib-mating. (Nov 4, 2009) 
 Strain Characteristics White, chalk-like abnormal incisors. The <i>whitich chalk-like teeth</i> (<i>wct</i>) mutation maps to rat chromosome 14 between D14Got13 and D14Wox2 (Masuyama, 2005). 
 Breeding Conditions normal (+/-) × mutant (-/-). Sib mating. 
 Genotyping  
 References  Masuyama T, Miyajima K, Ohshima H, Osawa M, Yokoi N, Oikawa T, Taniguchi K.
A novel autosomal-recessive mutation, whitish chalk-like teeth, resembling amelogenesis imperfecta, maps to rat chromosome 14 corresponding to human 4q21.
Eur J Oral Sci. 2005 Dec;113(6):451-6.

Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H.
Rat wct mutation prevents differentiation of maturation-stage ameloblasts resulting in hypo-mineralization in incisor teeth.
Histochem Cell Biol. 2007 Sep;128(3):183-93.

Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H.
Rat wct mutation induces a hypo-mineralization form of amelogenesis imperfecta and cyst formation in molar teeth.
Cell Tissue Res. 2007 Oct;330(1):97-109.