Japanese
 NBRP Rat No: 0509 Strain Name: SHR/NCrlCrlj Commmon Name: 
 Principal Investigator  Shinya Takahashi
 Organization   Charles river laboratories Japan 
 Address  11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama

222-0033 Kanagawa

  Japan
 Telephone  045（474）9340  Fax:  045（474）9341  web_order@jp.crl.com
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin This strain was established from Okamoto by selective mating of spontaneous hypertension rat from Wistar Kyoto rats in 1959. To NIH from Okamoto in 1966 at F13. To Charles River Laboratories, Inc. from NIH in 1973 at F32. To Charles River Japan, Inc. in 1980 at F51. (May 27, 2010) 
 Strain Characteristics Animal model for hypertension. The control strain is WKY. (May 27, 2010) 
 Breeding Conditions  
 Genotyping  
 References  Gandolgor TA, Ohara H, Cui ZH, Hirashima T, Ogawa T, Saar K, Hübner N, Watanabe T, Isomura M, Nabika T.
Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/izm.
Hypertension. 2013 Jul;62(1):55-61. doi: 10.1161/HYPERTENSIONAHA.111.00488. Epub 2013 May 20.