Strain information

Back to the list 433 / 882

NBRP Rat No: 0509

Strain name: SHR/NCrlCrlj

Commmon Name:

Rat Genome Database

Principal Investigator:

Shinya TakahashiCharles river laboratories Japan

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

../images/Photos/SHR_Crj/SHR%20Crj001%20(Large).JPG

../images/Photos/SHR_Crj/SHR%20Crj%20(Large).JPG

Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

This strain was established from Okamoto by selective mating of spontaneous hypertension rat from Wistar Kyoto rats in 1959. To NIH from Okamoto in 1966 at F13. To Charles River Laboratories, Inc. from NIH in 1973 at F32. To Charles River Japan, Inc. in 1980 at F51. (May 27, 2010)

Strain characteristics

Animal model for hypertension. The control strain is WKY. (May 27, 2010)

Breeding Conditions

Genotyping

References

Gandolgor TA, Ohara H, Cui ZH, Hirashima T, Ogawa T, Saar K, Hübner N, Watanabe T, Isomura M, Nabika T.
Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/izm.
Hypertension. 2013 Jul;62(1):55-61. doi: 10.1161/HYPERTENSIONAHA.111.00488. Epub 2013 May 20.

Additional strain information (Japanese only)