Strain information

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NBRP Rat No: 0220

Strain name: RICO/Ngs

Commmon Name: rat with increased cholesterol

Rat Genome Database

Principal Investigator:

Kazutaka OhsawaCenter for Frontier Life Sciences, Nagasaki University

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

F?+32 (May 2008)

Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

In 1969, 2 males and 4 females with spontaneous hypercholesterolemia were selected from different colonies of albino rats. By sib-mating and selective breeding, Muller et al. established this hypercholesterolemic strain and named RICO (rats with increased cholesterol) (Muller, 1979). 1997, from Australia ARC (animal resource centre) to Nagasaki University. (Nov 6, 2009)

Strain characteristics

hypercholesterolemia

Breeding Conditions

Sib mating. No selective breeding.

Genotyping

References

Production hepatique et intestinale de cholesterol augmentee, et quantite augmentee de cholesterol circulant. MULLER et ai., 1979

Müller KR, Li JR, Dinh DM, Subbiah MT.
The characteristics and metabolism of a genetically hypercholesterolemic strain of rats (RICO).
Biochim Biophys Acta. 1979 Aug 30;574(2):334-43.

Additional strain information (Japanese only)