Japanese
 NBRP Rat No: 0220 Strain Name: RICO/Ngs Commmon Name: rat with increased cholesterol
 Principal Investigator  Kazutaka Ohsawa
 Organization   Center for Frontier Life Sciences, Nagasaki University Division of Comparative Medicine
 Address  1-12-4, Sakamoto, Nagasaki

852-8523 Nagasaki

  Japan
 Telephone  095-819-7132  Fax:  095-819-7148  kohsawa@net.nagasaki-u.ac.jp
 Inbred Generations   F?+32 (May 2008) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin In 1969, 2 males and 4 females with spontaneous hypercholesterolemia were selected from different colonies of albino rats. By sib-mating and selective breeding, Muller <i>et al.</i> established this hypercholesterolemic strain and named RICO (rats with increased cholesterol) (Muller, 1979). 1997, from Australia ARC (animal resource centre) to Nagasaki University. (Nov 6, 2009) 
 Strain Characteristics hypercholesterolemia 
 Breeding Conditions Sib mating. No selective breeding. 
 Genotyping  
 References  Production hepatique et intestinale de cholesterol augmentee, et quantite augmentee de cholesterol circulant. MULLER et ai., 1979

M&uuml;ller KR, Li JR, Dinh DM, Subbiah MT.
The characteristics and metabolism of a genetically hypercholesterolemic strain of rats (RICO).
Biochim Biophys Acta. 1979 Aug 30;574(2):334-43.