Japanese
 NBRP Rat No: 0241 Strain Name: DRH.F344-Drh1/Shigm Commmon Name: DRH.F344-<i>Drh1</i>
 Principal Investigator  Hiroshi Hiai
 Organization   Graduate School of Medicine, Kyoto University Department of Pathology and Biology of Diseases
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  Japan
 Telephone  075-753-4421  Fax:  075-753-4432  hiai@shigamed.jp
 Inbred Generations   N16F30 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature(s) designated by the DEPOSITOR is requested.(see References) 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin The DRH is an inbred rat strain established by selective breeding of the 3'-Me-DAB resistant progeny of closed colony Donryu rats over 20 generations. Genetic analysis shows that two semidominant QTLs, Drh1 and Drh2, are responsible for strong resistance to chemical-induced hepatocarcinogenesis in DRH rats. Inbred DRH and F344 rats were purchased from SEAC Yoshitomi Co. DRH. 
 Strain Characteristics  
 Breeding Conditions Sib mating. 
 Genotyping  
 References  Zeng ZZ, Higashi S, Kitayama W, Denda A, Yan Y, Matsuo K, Konishi Y, Hiai H, Higashi K.
Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats.
Cancer Res. 2000 Jun 1;60(11):2876-81.

Yan Y, Zeng ZZ, Higashi S, Denda A, Konishi Y, Onishi S, Ueno H, Higashi K, Hiai H.
Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.
Carcinogenesis. 2002 Jan;23(1):189-96.

Liu H, Nobumoto K, Yamada Y, Higashi K, Hiai H.
Modulation of genetic resistance to hepatocarcinogenesis in DRH rats by partial hepatectomy.
Cancer Lett. 2003 Jun 30;196(1):13-6.

Higashi K, Hiai H, Higashi T, Muramatsu M.
Regulatory mechanism of glutathione S-transferase P-form during chemical hepatocarcinogenesis: old wine in a new bottle.
Cancer Lett. 2004 Jun 25;209(2):155-63.

Liu H, Higashi K, Hiai H.
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Cancer Sci. 2005 Mar;96(3):164-9.