Japanese
 NBRP Rat No: 0242 Strain Name: HAA/FDSC Commmon Name: HAA, Hatano高回避ラット、Hatano high-avoidance
 Principal Investigator  Ryo Ohta
 Organization   Hatano Research Institute, Food and Drug Safety Center Safety Testing Laboratory
 Address  729-5, Ochiai, Hadano

257-8523 Kanagawa

  Japan
 Telephone  0463-82-4751  Fax:  0463-82-9627  ohta.r@fdsc.or.jp
 Inbred Generations   F67 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin HAA (NBRP No.0242) and LAA (NBRP No.0243) strains of Hatano rats were originally selected and bred from Sprague-Dawley rats for their performance in the shuttle-box task at Hatano Research Institute in 1985 (Ohta, 1995). (Jun 17, 2009) 
 Strain Characteristics HAA rats show high-avoidance in a shuttle-box avoidance task. As compared to HAA, LAA offspring showed lower body weight, delayed eye opening, poorer performance in pivoting and negative geotaxis, and increased open-field activity (Ohta, 1998). Peak level of plasma ACTH during stress condition is significantly higher in this strain (Ohta, 1999, Asai, 2004) and is susceptible to gastric ulceration (Asai, 2006). (Jun 17, 2009) 
 Breeding Conditions  
 Genotyping  
 References  Ryo Ohta, Fumiaki Kumagai, Hideki Marumo, Kenji Usumi, Yoshiaki Saito, Makiko Kuwagata.
Stress-reactive rats (high-avoidance female rats) have a shorter lifespan than stress-nonreactive rats (low-avoidance female rats).
Journal of Toxicologic Pathology. Article ID: 2015-0045

Asai S, Ohta R, Shirota M, Watanabe G, Taya K.
Differential responses of the hypothalamo-pituitary-adrenocortical axis to acute restraint stress in Hatano high- and low-avoidance rats.
J Endocrinol. 181:515-520, 2004.

Shirota M, Sato M, Kojima K, Ohta R.
Minor involvement of somatic growth in the onset of puberty of Hatano high- and low-avoidance rats.
Reproduction. 127:389-395, 2004.

Asai S, Ohta R, Shirota M, Sato M, Watanabe G, Taya K
Reproductive endocrinology in Hatano high- and low-avoidance rats during the estrous cycle.
Endocrine 18:161-166, 2002.

Ohta R, Shirota M, Tohei A, Taya K.
Maternal behavior, milk ejection, and plasma hormones in Hatano high- and low-avoidance rats.
Horm Behav. 42:116-125, 2002.

Sato M, Ohta R, Kojima K, Shirota M.
Strain differences in the spontaneous incidence of sperm morphological abnormalities in Hatano rats.
J Vet Med Sci. 64:389-390, 2002.

Sato M, Ohta R, Kojima K, Shirota M., Koibuchi H, Asai S, Watanabe G, Taya K.
A comparative study of puberty, and plasma goadotropin and testicular hormone levels in two inbred strains of Hatano rats.
Journal of Reproduction and Development 48:111-119, 2002.

Sato M, Ohta R, Kojima K, Shirota M.
Differences in sperm motion between high- and low-shuttlebox avoidance rats (Hatano strains).
J Androl. 23:250-258, 2002.

Ohta R, Matsumoto A, Sato M, Shirota M, Nagao T, Tohei A, Taya K.
Postnatal behavior in hatano high- and low-avoidance rats following prenatal exposure to low-dose methylazoxymethanol.
Neurotoxicol Teratol. 22:405-413, 2000.

Ohta R, Shirota M, Adachi T, Tohei A, Taya K.
Plasma ACTH levels during early, two-way avoidance acquisition in high- and low-avoidance rats (Hatano strains).
Behav Genet. 29:137-144, 1999.

Ohta R, Matsumoto A, Nagao T, Mizutani M.
Comparative study of behavioral development between high and low shuttlebox avoidance rats.
Physiol Behav. 15;63:545-551, 1998.

Ohta R, Matsumoto A, Hashimoto Y, Nagao T, Mizutani M.
Behavioral characteristics of micrencephalic rats in high and low shuttlebox avoidance lines.
Neurotoxicol Teratol. 19:157-162, 1997.

Ohta R, Matsumoto A, Hashimoto Y, Nagao T, Mizutani M.
Behavioral characteristics of rats selectively bred for high and low avoidance shuttlebox response.
Congenital Anomalies 35:223-229, 1995.

Asai S, Ohta R, Fujikawa T, Sakai RR, Shirota M, Ogata M, Watanabe G, Taya K.
Gastric ulceration and expression of prolactin receptor in the brain in Hatano high- and low-avoidance rats.
Endocrine. 30(2):161-6, 2006.

Jaroenporn S, Nagaoka K, Ohta R, Watanabe G, Taya K.
Prolactin induces phosphorylation of the STAT5 in adrenal glands of Hatano rats during stress.
Life Sci. 2009 May 28.