Japanese
 NBRP Rat No: 0259 Strain Name: WF/Kop Commmon Name: Wistar Furth
 Principal Investigator  Ichiro Semba
 Organization   Kagoshima University Department of Oral Pathology, Filed of Oncology, Graduate School of Medical and Dental Sciences
 Address  8-35-1, Sakuragaoka

890-8544 Kagoshima

  Japan
 Telephone  099-275-6142  Fax:  099-275-6148  semba@dent.kagoshima-u.ac.jp
 Inbred Generations   F103+26 (April 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested.
Kitano, M., Hatano, H. and Shisa, H.
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Jpn. J. Cancer Res. 1992, 83: 843-50. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin J Furth established this strain from Wistar with a predilection for leukemia in 1945. Transferred to Hiroshima University, to Saitama Cancer Center in 1976, and to Kagoshima University Faculty of Dentistry in 1986. Other names are Wistar Furth and W/Fu. (Aug 17, 2010) 
 Strain Characteristics WF rats were resistant to 4NQO-induced tongue carcinomas (Kitano, 1992; Kitano, 1996). Genetic analysis identified five significant QTLs, <i>Tscc1</i>, <i>2</i>, <i>3</i>, <i>4</i>, <i>5</i> (Other names are <i>Tcas5</i>, <i>6</i>, <i>2</i>, <i>3</i>, <i>4</i>, respectively) (Tanuma, 1998; Tanuma, 2001). Several congenic lines carrying these QTL regions have been established (Please refer to NBRP No. 0265-0269). Class I MHC of the WF rat is RT1<sup>u</sup>. (Aug 17, 2010) 
 Breeding Conditions  
 Genotyping  
 References  Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.

化研紀要 33:3-12, 2002

Kitano M, Hatano H, Shisa H.
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Jpn J Cancer Res. 1992 Aug;83(8):843-50.

Kitano M, Hirayama Y, Tanuma J, Matsuuchi H, Miura Y, Li TJ, Semba I, Ozaki HS, Kokubu T, Hatano H, Tada M, Kobayashi Y, Shisa H.
Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.
Jpn J Cancer Res. 87(11):1097-101, 1996.

Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M.
Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
Cancer Res. 15;58(8):1660-4, 1998.

Tanuma JI, Fujii K, Hirano M, Matsuuchi H, Shisa H, Hiai H, Kitano M.
Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.
Jpn J Cancer Res. 2001 Jun;92(6):610-6.