NBRP Rat No: 0260 Strain NameBB/OK Commmon Name: 
 Principal Investigator  Ingrid Kloting
 Organization   University of Greifswald Laboratory Animal Science
 Address  Greifswalder Str. 11

17495 Karlsburg

 Telephone  +4938348619261  Fax:  +4938348619111  kloeting@uni-greifswald.de
 Inbred Generations   F62 
 Coat Color
 Deposition Status
 albino (a,b,c,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin 1983 outbred animals from Bio Breeding Laboratories, Ottawa, Canada ---> Karlsburg,start with inbreeding
 Strain Characteristics 80-100% of male and female BB/OK rats develop spontaneously insulin-dependent type 1 diabetes mellitus at an age of about 90 to 130days; first autoantobodies are detectable at an age of 10 days; first sign of insulitis at an age of 30 days; all animals develop insulitis up to an age of 30 weeks. 
 Breeding Conditions  
 References  Stark,O.,Kloting,I.,Reiher,K. and K.D. Kohnert
The major histocompatibility complex and insulin-dependent diabetes in BB rats. Acta biol.med. germ.41,1982,1129-1133

Kloting, I., Hubner, R. and O. Stark
Major histocompatibility complex (MHC)-independent differences between diabetes-prone BB rats and their parental Wistar rat strain in some hematologic and metabolic traits. Res. Exp. Med.182,1983,231-236

Kloting, I., O. Stark and H.J. Hahn
Animal model of the insulin-dependent diabetes mellitus in BB rats: Their RT1u homogeneity and prolonged survival of allogeneic skin grafts. Folia Biol.30,1984,24-32

Kloting, I., Stark, O. and R. Brdicka
Incidence of insulin-dependent diabetes mellitus in BB rats: Their genetic heterogeneity and susceptibility to infection. Folia Biol.30,1984,33-42

Kloting, I. and Stark, O.
Results of the local graft-versus-host reaction support the immunogenetic concept of the insulin-dependent diabetes mellitus in BB rats. Folia Biol.30,1984,202-208

Kloting, I. und K. Reiher
Einige Aspekte zur Haltung und Reproduktion spontandiabetischer BB-Ratten. Z.Versuchstierkd.27,1985,5-12

Kloting, I. and O. Stark
Occurrence of antibodies against gene products of the major histocompatibility complex in normal sera of diabetes-prone BB rats. Folia Biol.31,1985,34-37

Kloting, I. and O. Stark
Genetic studies of IDDM in BB rats: The incidence of diabetes in F2 and first backcross hybrids allows rejection of recessive hypothesis. Exp.Clin.Endocrinol.89,1987,312-318

Kloting, I., Vogt, L., Stark, O.and U. Fischer
Genetic heterogeneity in different BB rat subpopulations. Diabetes Res.6,1987,145-149

Knospe, S., Kohler, E. and I. Kloting
Cell-mediated immune reactions against islets of Langerhans in diabetes-prone BB rats. Exp.Clin.Endocrinol.89,1987,290-296

Ziegler, B., Kloting, I., Besch, W., Ziegler, M. and H.J. Hahn
Cytotoxic activity of sera from diabetic BB rats against BB rat islet-a functional study. Diabetes Res. 4,1987,67-72

Kloting, I. and L. Vogt
Breeding problems in diabetes-prone BB rats after "wet hysterectomy". Z.Versuchstierkd.31, 1988,19-22

Hehmke, B., Schröder, D. and I. Kloting
Early appearance of complement-dependent antibody-mediated cytotoxicity (C , AMC) to islet cells in serum of diabetes-prone BB/OK rats. Diabetes Res.15,1990,183-186

Vogt, L. and I. Kloting
Breeding management of BB rats by the aid of the computer program BB_RADABA. J.Exp.Anim.Sci.35,1992,34,184-188

Kloting, I. and L. Vogt
BB/O(ttawa)K (arlsburg) rats: Features of a subline of diabetes-prone BB rats.Diabetes Res., 1991,18,79-87

Dunger, A., Kloting, I., Besch, W. and H.J. Hahn
The effect of serum concentration and sources on DNA synthesis and insulin secretion of cultured islets. Exp.Clin.Endocrinol.99, 1992, 34-38

Kloting, I. and L. Vogt
On the influence of metabolic state of parents at conception and pregnancy on incidence and age at onset of diabetes in the progeny of BB/OK rats. Diabetes Res. 19,1992, 37-40

Kloting, I., Voigt B. and L. Vogt
Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as a tool to search for candidate loci causing different phenotypes in BB rats. Diabetes Res. 29, 1995, 65-71

Lucke, S., Kloting, I., Pusch, A., Heinrich, H.W. and H.J. Hahn
Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X. Autoimmunity 36, 2003, 143-149

Hahn, H.J., Lucke, S., Kloting, I. and W. Besch
Prospective investigations of long-term normoglycaemic BB/OK-rats: Serial determination of glucose tolerance, insulitis, B-cell volume density and pancreatic insulin content. Exp.Clin.Endocrinol.98, 1991, 185-192