NBRP Rat No: 0264 Strain NameWOKW/K Commmon Name: WOKW
 Principal Investigator  Ingrid Kloting
 Organization   University of Greifswald Laboratory Animal Science
 Address  Greifswalder Str. 11

17495 Karlsburg

 Telephone  +4938348619261  Fax:  +4938348619111  kloeting@uni-greifswald.de
 Inbred Generations   F68 
 Coat Color
 Deposition Status
 albino (a,b,c,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Outbred Wistar rats were transferred from the BioBreeding Laboratories in Ottawa, Canada, to the Institute of Pathophysiology (formerly the Institute of Diabetes Gerhardt Katsch) in Karlsburg, Germany in 1981. By selective breeding of RT1<sup><i>a</i></sup> or RT1<sup><i>u</i></sup> homozygous from the outbred Wistar rats, two inbred lines were generated as WOK.1A (Wistar Ottawa Karlsburg RT1<sup><i>a</i></sup>) or WOK.1W respectively (Kov&#225;cs, 1997). Wistar Ottawa Karlsburg W. (Sep 16, 2010) 
 Strain Characteristics WOKW rats and BB/OK rats were originated from the same colony of Wistar rat and both strains possess RT1<i>u</i> haplotype (Kov&#225;cs, 1997). WOKW rats develop polygenic inherited metabolic syndrome resembling human disorder such as obesity, dyslipidemia, impaired glucose tolerance (IGT), hyperinsulinemia and hyperleptinemia (Kov&#225;cs, 1997; Kov&#225;cs, 2000; van den Brandt, 2000; van den Brandt, 2002). By breeding analysis of disease-prone WOKW and disease-resistant DA rats, several QTLs associated with metabolic syndrome were mapped (Kov&#225;cs, 2000; Kl&#246;ting, 2001; Baguhl, 2009). Some of them were sex-specific. (Sep 16, 2010) 
 Breeding Conditions  
 References  Kloting I, Voigt B. and L Vogt.
Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as a tool to search for candidate loci causing different phenotypes in BB rats.
Diabetes Res. 29, 65-71, 1995.

Kov&aacute;cs P, van den Brandt J, Kl&ouml;ting I.
Genetic dissection of the syndrome X in the rat.
Biochem Biophys Res Commun. 269(3):660-5, 2000.

van den Brandt J, Kov&#225;cs P, Kl&#246;ting I.
Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg W (RT1u haplotype) rat.
Metabolism. 2000 Sep;49(9):1140-4.

van den Brandt J, Kovacs P, Kl&#246;ting I.
Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats.
Int J Obes Relat Metab Disord. 2002 Apr;26(4):573-6.

Kl&#246;ting I, Kov&#225;cs P, van den Brandt J.
Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats.
Biochem Biophys Res Commun. 2001 Jun 1;284(1):150-6.

Schreyer S, Ledwig D, Rakatzi I, Kl&ouml;ting I, Eckel J.
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
Endocrinology. 144(4):1211-8, 2003.

Kov&aacute;cs P, Voigt B, Berg S, Vogt L, Kl&ouml;ting I.
WOK.1W rats. A potential animal model of the insulin resistance syndrome.
Ann N Y Acad Sci. 20;827:94-9, 1997.

Baguhl R, Wilke B, Kl&#246;ting N, Kl&#246;ting I.
Genes on rat chromosomes 3, 5, 10, and 16 are linked with facets of metabolic syndrome.
Obesity (Silver Spring). 2009 Jun;17(6):1215-9. Epub 2009 Feb 19.