Japanese
 NBRP Rat No: 0261 Strain Name: BB.SHR-(D4Got41-Tacr1)/K Commmon Name: BB.SHR-(<i>D4Got41-Tacr1</i>)
 Principal Investigator  Ingrid Kloting
 Organization   University of Greifswald Laboratory Animal Science
 Address  Greifswalder Str. 11

17495 Karlsburg

  Germany
 Telephone  +4938348619261  Fax:  +4938348619111  kloeting@uni-greifswald.de
 Inbred Generations   N5F12 
   
 Coat Color
 Deposition Status
 
 albino (a,b,c,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Congenic BB.LL rats were established as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats and marker-aided selection in 1997.
 
 Strain Characteristics Animals are not hypertensive, but develop an incomplete metabolic syndrome with obesity, hyperleptinemia and dyslipidemia.
About 70% of animals are prone to apoplectic stroke. 
 Breeding Conditions  
 Genotyping  
 References  Kloting I, Kovacs P, Kuttler B.
Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat.
Biochem Biophys Res Commun. 1997 Oct 9;239(1):106-10.

Kovacs P, van den Brandt J, Bonne AC, van Zutphen LF, van Lith HA, Kloting I.
Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet.
Metabolism. 2001 50(4):458-62.

Kloting I, Kovacs P. and van den BrandtJ
Congenic BB.SHR (D4Mit6-Npy-Spr) rats: A new aid to dissect the genetics of obesity.
Obes Res. 2002 10(10):1074-7.

Lucke S, Kloting I, Pusch A, Heinrich HW and Hahn HJ
Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X.
Autoimmunity. 2003 36(3):143-9.