Usage Restrictions
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Origin
Congenic BB.LL rats were established as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats and marker-aided selection in 1997.
Strain characteristics
Animals are not hypertensive, but develop an incomplete metabolic syndrome with obesity, hyperleptinemia and dyslipidemia.
About 70% of animals are prone to apoplectic stroke.
References
Kloting I, Kovacs P, Kuttler B.
Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat.
Biochem Biophys Res Commun. 1997 Oct 9;239(1):106-10.
Kovacs P, van den Brandt J, Bonne AC, van Zutphen LF, van Lith HA, Kloting I.
Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet.
Metabolism. 2001 50(4):458-62.
Kloting I, Kovacs P. and van den BrandtJ
Congenic BB.SHR (D4Mit6-Npy-Spr) rats: A new aid to dissect the genetics of obesity.
Obes Res. 2002 10(10):1074-7.
Lucke S, Kloting I, Pusch A, Heinrich HW and Hahn HJ
Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X.
Autoimmunity. 2003 36(3):143-9.