Japanese
 NBRP Rat No: 0262 Strain Name: BB.SHR-(D6Rat184-D6Rat3)/K Commmon Name: BB.SHR-(<i>D6Rat184-D6Rat3</i>)
 Principal Investigator  Ingrid Kloting
 Organization   University of Greifswald Laboratory Animal Science
 Address  Greifswalder Str. 11

17495 Karlsburg

  Germany
 Telephone  +4938348619261  Fax:  +4938348619111  kloeting@uni-greifswald.de
 Inbred Generations   N8F8 
   
 Coat Color
 Deposition Status
 
 albino (a,b,c,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Congenic BB.6S rats were established by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats in 2000.
 
 Strain Characteristics Diabetes frequency is significantly decreased in comparison with parental BB/OK rats
(15 vs. 86%).Animals are heavier and serum lipids are increased compared with BB/OK. 
 Breeding Conditions  
 Genotyping  
 References  Kloting I, Schmidt S, Kovacs P.
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.
Biochem Biophys Res Commun. 1998 Apr 17;245(2):483-6.

Kloting I, Van Den Brandt J, Kov&#225;cs P.
Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.
Int J Mol Med. 1998 Nov;2(5):597-601.

Kloting I, van den Brandt J, Kuttler B.
Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.
Biochem Biophys Res Commun. 2001 May 4;283(2):399-405.