Origin |
DA rats are highly susceptible to 4NQO-induced tongue carcinoma, whereas WF rats are barely susceptible (Kitano, 1992). To establish this congenic strain, QTL region <i>Tscc1</i> (Tongue squamous cell carcinoma 1, alias <i>Tcas5</i> RGD: 724565), <i>Tscc4</i> (alias <i>Tcas3</i> RGD: 631261), <i>Tscc2</i> (alias <i>Tcas6</i> RGD: 724567) were introgressed from WF rat to DA rat background (Tanuma, 1998; Tanuma, 2001). (Aug 20, 2010) |
References |
Kitano M, Hatano H, Shisa H. Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats. Jpn J Cancer Res. 1992 Aug;83(8):843-50.
Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Cancer Res. 15;58(8):1660-4, 1998.
Tanuma JI, Fujii K, Hirano M, Matsuuchi H, Shisa H, Hiai H, Kitano M. Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat. Jpn J Cancer Res. 2001 Jun;92(6):610-6. |