NBRP Rat No: 0506 Strain NameF344/DuCrlCrlj Commmon Name: 
 Principal Investigator  Shinya Takahashi
 Organization   Charles river laboratories Japan 
 Address  11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama

222-0033 Kanagawa

 Telephone  045(474)9340  Fax:  045(474)9341  web_order@jp.crl.com
 Inbred Generations    
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin This strain is originated from Fischer344 which transferred from Dr. Dunning to Charles River Laboratories, Inc., 1960 at F68. Breeding under SPF condition has started in 1965 at F81 and F110 rats were transferred to Charles River Japan, Inc. in 1976. (May 27, 2010) 
 Strain Characteristics Small size, docile. (May 27, 2010)<br />This strain has a missense mutation (Gly633Arg) in DIPEPTIDYL PEPTIDASE IV(Dpp4)gene. The functional DPP4 protein is not expressed in this strain. (July 7, 2016).
 Breeding Conditions Good breeding performance. (May 27, 2010) 
 References  Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157

Nakanishi S, Serikawa T, Kuramoto T.
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.
Exp Anim. 64(1):25-29, 2015.<br />
Biochemistry. 1992 Dec 1;31(47):11921-7.
An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.
Tsuji E1, Misumi Y, Fujiwara T, Takami N, Ogata S, Ikehara Y.