Japanese
 NBRP Rat No: 0083 Strain Name: F344.Cg-Foxn1rnu/Kyo Commmon Name: F344/N-<i>Foxn1<sup>rnu</sup></i>/Kyo, F344/N-rnu
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F?+57 (March 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c,rnu)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Foxn1: forkhead box N1
 Origin This congenic strain was established as a strain with the genetic background of F344/N onto which a segment from the nude rat containing the <i>Foxn1<sup>rnu</sup></i> was transferred.
Originally, hairless mutant (<i>rnu</i>) was observed in a colony of outbred hooded rats maintained at the Rowett Research Institute in Scotland (Festing, 1978). Backcrossing started at Central Institute for Experimental Animals in 1979 and thereafter the subline was transported to the Institute of Laboratory Animals Graduate School of Medicine, Kyoto University. (Mar 25, 2010) 
 Strain Characteristics <i>rnu</i>/<i>rnu</i> lacks normal thymus and functionally mature T cells, and is characterized by hairlessness (thinning hair) but usually exhibits short and thin hairs and has hair cycle (Festing, 1978; Hedrich, 1990). Life span is shorter under the conventional condition compared to under the SPF condition. <i>rnu</i>/+ is smaller than <i>rnu</i>/<i>rnu</i>.
<i>rnu</i> was mapped on rat chromosome 10 in the q24-q32 interval (Kuramoto, 1993), and identified as a nonsense mutation (1429C>T) of <i>Foxn1</i> (alias <i>Whn</i>) gene (Serge, 1995).
Similar mutant rat independently arose in a colony of randomly bred albino rats in New Xealand (Berridge, 1979、Nehls, 1994). (Mar 25, 2010) 
 Breeding Conditions Good breeding performance. Sib mating between heterozygous female and homozygous male are mated. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Foxn1_rnu_en.pdf">Genotyping protocol for Foxn1</a> 
 References  Festing MF, May D, Connors TA, Lovell D, Sparrow S.
An athymic nude mutation in the rat.
Nature. 1978 Jul 27;274(5669):365-6.

Vos JG, Kreeftenberg JG, Kruijt BC, Kruizinga W, Steerenberg P.
The athymic nude rat. II. Immunological characteristics.
Clin Immunol Immunopathol. 1980 Feb;15(2):229-37.

Rolstad B.
The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?
Immunol Rev. 2001 Dec;184:136-44.

Hedrich H
Mutant genes and polymorphic loci of the laboratory rat.
In H.J.Hedrich (ed.): Genetic Monitoring of the Inbred Strains of Rats, pp377-380, Gustav Fisher Stuttgart, New York 1990.

Kuramoto T, Serikawa T, Hayasaka N, Mori M, Yamada J.
Regional mapping of the Rowett nude gene (RONU) to rat chromosome 10q24-->q32 by localizing linked SYB2 and GH loci.
Cytogenet Cell Genet. 1993;63(2):107-10.

Segre JA, Nemhauser JL, Taylor BA, Nadeau JH, Lander ES.
Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat.
Genomics. 1995 Aug 10;28(3):549-59.

Berridge MV, O'Kech N, McNeilage LJ, Heslop BF, Moore R.
Rat mutant (NZNU) showing "nude" characteristics.
Transplantation. 1979 Jun;27(6):410-3.

Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T.
New member of the winged-helix protein family disrupted in mouse and rat nude mutations.
Nature. 1994 Nov 3;372(6501):103-7.