Japanese
 NBRP Rat No: Strain Name: HOB (hob/+) Commmon Name: hobble rat
 Principal Investigator  Yosuke Ando
 Organization   DAIICHI SANKYO Co., Ltd. Medicinal Safety Research Laboratories
 Address  717, Horikoshi, Fukuroi-shi

437-0065 Shizuoka

  JAPAN
 Telephone  0538-42-4356  Fax:  0538-42-4350  ando.yosuke.x8@daiichisankyo.co.jp
 Inbred Generations   F13+12 
   
 Coat Color
 Deposition Status
 
 a,B,C,h
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13. 
 Strain Characteristics Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus. 
 Breeding Conditions Maintained by brather-sister matings between hob/+ males and hob/hob females. Good breeding performance. 
 Genotyping PCR-RFLP（see Kuramoto et al. Mol. Brain Res. 122(2): 103-108, 2004) 
 References  第44回日本実験動物学会総会　講演要旨集P145　1997大宮市

Kuwamura, M., Ando, Y., Takeda, A., Kanehara, T., Yamane, J., Kotani, T., Takeshita, S., Kanbori, M., Kitada, K., Serikawa, T.
Rat mutations cvd and hob with cerebellar malformations map to chromosome 2.
Exp. Anim. 53(1): 21-26, 2004.

Kuramoto, T., Kuwamura, M., Serikawa, T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Mol. Brain Res. 122(2): 103-108, 2004.