NBRP Rat No: Strain NameODS/ShiJcl Commmon Name: Osteogenic disorder Shionagi rat
 Principal Investigator  Mieko Kimura
 Organization   Takeda hospital group Takeda Research Institute of Life Science

604-8113  Kyoto

 Telephone  +082-75-468-9735  Fax:  +082-231-2310  kimura@takedahp.or.jp
 Inbred Generations    
 Coat Color
 Deposition Status
  Embryo      Sperm      Live Animals
 Usage Restrictions  not deposited to NBRP 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Gulo: gulonolactone (L-) oxidase
 Strain Characteristics scurvy due to L-gulonolactone oxidase deficincy; phenotype normalizes if supplied with ascorbic acid 300mg/kg/d. od/od rats are more susceptible to dental caries as compared with +/+ rats, in only amoun parous females. 
 Breeding Conditions  
 References  Nishijima K, Kuwahara S, Ohno T, Miyaishi O, Ito Y, Makino S, Sumi Y, Yanaka S
Natural dental caries in molars of Osteogenic disorder Shionogi rats.
Comp Med. 2007 Dec;57(6):590-3