Origin |
Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-<i>Atrn<sup>zi</sup></i> congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-<i>Kcnq1<sup>dfk</sup></i>/Kyo rat is a mutant for circling behavior. although the Atrn<sup>zi</sup> allele of WTC.ZI-<i>Atrn<sup>zi</sup></i> congenic rats was eliminated, the circling behavior remained. |
References |
Gohma H, Kuramoto T, Kuwamura M, Okajima R, Tanimoto N, Yamasaki K, Nakanishi S, Kitada K, Makiyama T, Akao M, Kita T, Sasa M, Serikawa T. WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions. Physiol Genomics. 14;24(3):198-206, 2006.
Kuwamura M, Okajima R, Yamate J, Kotani T, Kuramoto T, Serikawa T. Pancreatic Metaplasia in the Gastro-achlorhydria in WTC-dfk Rat, a Potassium Channel Kcnq1 Mutant. Vet Pathol. 45(4):586-91, 2008. |