Japanese
 NBRP Rat No: 0289 Strain NameWTC-Kcnq1dfk/Kyo Commmon Name: WTC-<i>dfk</i>, deafness Kyoto
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F23 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOUCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Kcnq1: potassium voltage-gated channel, subfamily Q, member 1
 Origin Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-<i>Atrn<sup>zi</sup></i> congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-<i>Kcnq1<sup>dfk</sup></i>/Kyo rat is a mutant for circling behavior. although the Atrn<sup>zi</sup> allele of WTC.ZI-<i>Atrn<sup>zi</sup></i> congenic rats was eliminated, the circling behavior remained. 
 Strain Characteristics Abnormal behaviors such as head-tossing, drawing back, stepping back, and circling. Complete deafness. Inner ear of the WTC-dfk rats showed collapsed endolymph. Prolonged QT interval in the electrocardiogram (ECG) Gastric achlorhydria associated with hypertrophic gastric mucosa. 
 Breeding Conditions Both male and female rats are fertile. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Kcnq1_dfk_en.pdf">Genotyping protocol for Kcnq1</a> 
 References  Gohma H, Kuramoto T, Kuwamura M, Okajima R, Tanimoto N, Yamasaki K, Nakanishi S, Kitada K, Makiyama T, Akao M, Kita T, Sasa M, Serikawa T.
WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions.
Physiol Genomics. 14;24(3):198-206, 2006.

Kuwamura M, Okajima R, Yamate J, Kotani T, Kuramoto T, Serikawa T.
Pancreatic Metaplasia in the Gastro-achlorhydria in WTC-dfk Rat, a Potassium Channel Kcnq1 Mutant.
Vet Pathol. 45(4):586-91, 2008.