NBRP Rat No: 0378 Strain NameWKY/Ezo Commmon Name: 
 Principal Investigator  Hiroko Togashi
 Organization   Health Sciences University of Hokkaido Pharmaceutical Sciences
 Address  1757 Kanazawa, Tobetsu-cho, Ishikari-gun

061-0293 Hokkaido

 Telephone  0133-23-1211  Fax:  0133-23-1849  hirot@hoku-iryo-u.ac.jp
 Inbred Generations    
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing, an acknowledgment to the DEPOSITOR is requested.
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.

For a breeding use, a new contract must be concluded between the DEPOSITOR and the recipient.
After finishing the defined period in the contract, the recipient requires immediate stop of breeding.
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin This strain had maintained at Hokkaido University, School of Medicine from around 1980. F20 generation rats were transferred to Health Sciences University of Hokkaido in 1987. 
 Strain Characteristics Control strain for SHRSP/Ezo (NBRP No.0441). 
 Breeding Conditions There is a possibility that express gait abnormality in rare cases. 
 References  Ueno K-I, Togashi H, Mori K, Matsumoto M, Ohashi S, Hoshino A, Fujita T, Saito H, Minami M and Yoshioka M: Behavioural and pharmacological relevance of stroke-prone spontan eously hypertensive rats as an animal model of a developmental disorder. Behav Pharmacol 13: 1-13 (2002)

注意欠陥/多動性障害モデル, 幼若脳卒中易発症高血圧自然発症ラットの行動薬理学的特性 [ミニレビュー] 日本神経精神薬理学雑誌 (Jpn. J. Neuropsychopharmacol.) 23: 47-55 (2003)

Ueno K, Togashi H, Matsumoto M, Saito H, Yoshioka M.
Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder. Biogenic Amines 17 (4-6): 293-312 (2003)

Jesmin S, Togashi H, Sakuma I, Mowa CN, Ueno K, Yamaguchi T, Yoshioka M, Kitabatake A.
Gonadal hormones and frontocortical expression of vascular endothelial growth factor in male stroke-prone, spontaneously hypertensive rats, a model for attention-deficit/hyperactivity disorder.
Endocrinology. 2004 Sep;145(9):4330-43.

Togashi H, Ueno K, Yamaguchi T, Matsumoto M, Higuchi K, Saito H, Yoshioka M.
Anxiety-related behavior in juvenile stroke-prone spontaneously hypertensive rats - an animal model of attention-deficit/hyperactivity disorder.
Biogenic Amines 18(3-6): 247-261 (2004)